General Information

  • ID:  hor004123
  • Uniprot ID:  P85864
  • Protein name:  Pyrokinin
  • Gene name:  NA
  • Organism:  Schistocerca gregaria (Desert locust) (Gryllus gregarius)
  • Family:  Pyrokinin family
  • Source:  animal
  • Expression:  Found in the abdominal ganglia and perisympathetic organs. Not detected in the thoracic ganglia, subesophageal ganglion, corpora cardiaca, corpora allata, hypocerebral ganglion or frontal ganglion.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Schistocerca (genus), Cyrtacanthacridinae (subfamily), Acrididae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DGAETPGAAASLWFGPRV
  • Length:  18
  • Propeptide:  DGAETPGAAASLWFGPRV
  • Signal peptide:  NA
  • Modification:  T18 Valine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myoactive
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P85864-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    AF-P85864-F1.pdbhor004123_AF2.pdbhor004123_ESM.pdb

Physical Information

Mass: 210539 Formula: C81H120N22O25
Absent amino acids: CHIKMNQY Common amino acids: A
pI: 4.18 Basic residues: 1
Polar residues: 5 Hydrophobic residues: 8
Hydrophobicity: -1.67 Boman Index: -1209
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 60
Instability Index: 897.78 Extinction Coefficient cystines: 5500
Absorbance 280nm: 323.53

Literature

  • PubMed ID:  12504101
  • Title:  Mass Spectrometric Analysis of the Perisympathetic Organs in Locusts: Identification of Novel Periviscerokinins